The Skyline Team

At Skyline Therapeutics, we are turning our passion for science and our expertise in gene therapy into promising new treatments. Our work is guided by a commitment to fulfilling the unmet needs of patients. It urges us to pursue scientific breakthroughs that can only be possible through relentless innovation, a constant strive for quality, and team collaborations.

Join us

The fast-growing Skyline team provides a variety of opportunities for individuals to learn, grow, and create scientific excellence. Join us in our efforts to discover, develop and deliver transformative therapies that could bring life-changing benefits to patients.

Job openings
Location:
Position category:
Position Location Job Details
  • Investigator, Molecular Biology Shanghai

    Key Responsibilities:

    ·Design, construct, and optimize AAV transgenes for various pipeline programs

    ·Characterize the expression and activity AAV transgene in cells and animal tissues, optimize the transgene based on program need

    ·Develop and validate assays for characterizing the products encoded by AAV transgenes

    ·Plan and write protocols for in vitro characterization of AAV vectors

    ·Carry out small scale production of AAV vectors using triple transfection for both in vitro and in vivo studies

    ·Perform AAV vector purification, evaluate AAV vector quality by qPCR, silver staining, denaturing gel, and other assays

    ·Write, execute, and troubleshoot protocols, adapt new protocols into practice

    ·Analyze data from studies, summarize them and write study reports, and present results in various meetings

    ·Finish the other tasks assigned by the supervisor

    Qualifications:

    ·Ph.D. in Molecular/Cellular Biology/Biochemistry or related discipline

    ·2-5 years of hands-on experience in DNA cloning, transfection, protein expression and characterization

    ·Extensive knowledge and experience with molecular and cellular techniques

    ·Excellent track record in AAV transgene design, optimization, and characterization

    ·Experience with qPCR, PRT-PCR, and digital droplet PCR

    ·Outstanding communication and problem-solving skills

    ·Significant experience with managing collaborations with other laboratories and/or CROs

    ·Ability to be highly productive in a fast-paced, fluid, and team-oriented work environment

    ·Strong publication record in peer-reviewed journals

    To apply, send us email with your resume to career@skytx.com
  • Scientist, In Vitro Shanghai

    Key Responsibilities:

    ·Clone and prepare AAV transgene constructs for various programs

    ·Produce and perform plasmid purification by miniprep and maxiprep

    ·Maintain and culture mammalian cell lines, perform transient transfection for gene expression or AAV vector production at a small or medium scale

    ·Perform AAV vector purification, evaluate AAV vector quality by qPCR, silver staining, and other assays

    ·Characterize transgene expression mediated by AAV vector in cells and animal tissues using different molecular techniques

    ·Troubleshoot issues arisen during studies, modify the protocols accordingly, and adapt new protocols into practice

    ·Assist in preparing experimental work plans, writing protocols and technical reports

    ·Finish the other tasks assigned by the supervisor

    Qualifications:

    ·Bachelor/Master in Molecular Biology, Biochemistry or related discipline

    ·2 (bachelor) or 1 (Master) years hands-on experience in molecular cloning, transfection, and protein characterization

    ·Familiar with molecular biology techniques (RNA/DNA isolation, vector cloning, plasmid purification, Western blotting, silver staining, qPCR, ELISA, etc.)

    ·Capable of executing experiments following protocols, analyzing and presenting results in meetings

    ·Ability to multitask for multiple projects and to work in a fast-paced, highly interactive environment

    ·Self-motivated, organized with attention to detail, capable of working in a collaborative/group environment

    To apply, send us email with your resume to career@skytx.com
  • Analytical Development Manager/Senior Manager Shanghai

    Key Responsibilities:

    ·Direct analytical development activities for AAV and cell therapy programs.

    ·Support process development and process understanding by ensuring appropriate analytics are executed.

    ·Lead product characterization, and product attribute criticality assessments; Coordinate analytical method transfer and qualification.

    ·Keep up with technology trends in analytical mythologies and make recommendations for implementation of new methods and equipment.

    ·Present to cross functional teams and effectively communicate critical analytical issues and solutions

    ·Author and review development report, study protocols, SOPs and qualification/validation reports.

    ·Perform other duties as assigned.

    Qualifications:

    ·PhD degree in biological sciences or related field with at least 5 years relevant experience.

    ·Demonstrated experience in development of phase-appropriate analytics for release and characterization of biological products, preferably gene or cell therapy products.

    ·Strong technical knowledge across analytical development. Sound understanding of regulatory requirement related to INDs and BLAs.

    ·Demonstrated experience in developing various analytical techniques, such as cell-based assay, flow cytometry, PCR, ELISA, HPLC, etc. Deep understanding of statistical experimental design and data analysis.

    ·Demonstrated leadership skills, planning and organizational capabilities.

    ·Proven ability to work with a high level of integrity, accuracy, and attention to details

    ·Proven success in building and leading teams.

    ·Proficient written and spoken English.

    To apply, send us email with your resume to career@skytx.com
  • Scientist, In Vivo Pharmacology Shanghai

    Key Responsibilities:

    ·Execute in vivo studies using different animal models following protocols and study designs

    ·Perform animal necropsies including perfusion, tissues and blood collections, knowledge of tissues processing for IHC and in situ hybridization will be a plus

    ·Analyze and interpret results with high quality and reproducibility in a timely manner

    ·Participate in discussions in cross-disciplinary team and program meetings

    ·Contribute to writing study reports, study protocols, SOPs, and regulatory filings

    ·Finish the other tasks assigned by the supervisor

    Qualifications:

    ·A minimum of a bachelor with 2 years or a Master with 1 year of professional working experience in vivo drug discovery

    ·Working knowledge in in vivo pharmacology and strong expertise in animal handlings and various routes of drug administrations

    ·Ability to follow study protocols and execute in vivo studies with minimal supervision

    ·Self-motivated, organized, capable of working in a collaborative/group environment

    ·Ability to function and communicate effectively in a highly productive multi-disciplinary environment

    ·Excellent communication skills and enjoy work in a fast-paced and highly interactive environment

    To apply, send us email with your resume to career@skytx.com
  • Scientist, Downstream Process Development Shanghai

    Key Responsibilities:

    ·Execute in vivo studies using different animal models following protocols and study designs

    ·Perform animal necropsies including perfusion, tissues and blood collections, knowledge of tissues processing for IHC and in situ hybridization will be a plus

    ·Analyze and interpret results with high quality and reproducibility in a timely manner

    ·Participate in discussions in cross-disciplinary team and program meetings

    ·Contribute to writing study reports, study protocols, SOPs, and regulatory filings

    ·Finish the other tasks assigned by the supervisor

    Qualifications:

    ·A minimum of a bachelor with 2 years or a Master with 1 year of professional working experience in vivo drug discovery

    ·Working knowledge in in vivo pharmacology and strong expertise in animal handlings and various routes of drug administrations

    ·Ability to follow study protocols and execute in vivo studies with minimal supervision

    ·Self-motivated, organized, capable of working in a collaborative/group environment

    ·Ability to function and communicate effectively in a highly productive multi-disciplinary environment

    ·Excellent communication skills and enjoy work in a fast-paced and highly interactive environment

    To apply, send us email with your resume to career@skytx.com
  • Scientist, Upstream Process Development Shanghai

    Key Responsibilities:

    ·Execute in vivo studies using different animal models following protocols and study designs

    ·Perform animal necropsies including perfusion, tissues and blood collections, knowledge of tissues processing for IHC and in situ hybridization will be a plus

    ·Analyze and interpret results with high quality and reproducibility in a timely manner

    ·Participate in discussions in cross-disciplinary team and program meetings

    ·Contribute to writing study reports, study protocols, SOPs, and regulatory filings

    ·Finish the other tasks assigned by the supervisor

    Qualifications:

    ·A minimum of a bachelor with 2 years or a Master with 1 year of professional working experience in vivo drug discovery

    ·Working knowledge in in vivo pharmacology and strong expertise in animal handlings and various routes of drug administrations

    ·Ability to follow study protocols and execute in vivo studies with minimal supervision

    ·Self-motivated, organized, capable of working in a collaborative/group environment

    ·Ability to function and communicate effectively in a highly productive multi-disciplinary environment

    ·Excellent communication skills and enjoy work in a fast-paced and highly interactive environment

    To apply, send us email with your resume to career@skytx.com
  • Quality Assurance Specialist Hangzhou

    Key Responsibilities:

    ·Execute in vivo studies using different animal models following protocols and study designs

    ·Perform animal necropsies including perfusion, tissues and blood collections, knowledge of tissues processing for IHC and in situ hybridization will be a plus

    ·Analyze and interpret results with high quality and reproducibility in a timely manner

    ·Participate in discussions in cross-disciplinary team and program meetings

    ·Contribute to writing study reports, study protocols, SOPs, and regulatory filings

    ·Finish the other tasks assigned by the supervisor

    Qualifications:

    ·A minimum of a bachelor with 2 years or a Master with 1 year of professional working experience in vivo drug discovery

    ·Working knowledge in in vivo pharmacology and strong expertise in animal handlings and various routes of drug administrations

    ·Ability to follow study protocols and execute in vivo studies with minimal supervision

    ·Self-motivated, organized, capable of working in a collaborative/group environment

    ·Ability to function and communicate effectively in a highly productive multi-disciplinary environment

    ·Excellent communication skills and enjoy work in a fast-paced and highly interactive environment

    To apply, send us email with your resume to career@skytx.com
  • Production Specialist Hangzhou

    Key Responsibilities:

    ·Execute in vivo studies using different animal models following protocols and study designs

    ·Perform animal necropsies including perfusion, tissues and blood collections, knowledge of tissues processing for IHC and in situ hybridization will be a plus

    ·Analyze and interpret results with high quality and reproducibility in a timely manner

    ·Participate in discussions in cross-disciplinary team and program meetings

    ·Contribute to writing study reports, study protocols, SOPs, and regulatory filings

    ·Finish the other tasks assigned by the supervisor

    Qualifications:

    ·A minimum of a bachelor with 2 years or a Master with 1 year of professional working experience in vivo drug discovery

    ·Working knowledge in in vivo pharmacology and strong expertise in animal handlings and various routes of drug administrations

    ·Ability to follow study protocols and execute in vivo studies with minimal supervision

    ·Self-motivated, organized, capable of working in a collaborative/group environment

    ·Ability to function and communicate effectively in a highly productive multi-disciplinary environment

    ·Excellent communication skills and enjoy work in a fast-paced and highly interactive environment

    To apply, send us email with your resume to career@skytx.com